Introduction – Company Background
GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.
With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.
With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.
From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.
At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.
By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.
Core Strengths in Insole Manufacturing
At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.
Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.
We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.
With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.
Customization & OEM/ODM Flexibility
GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.
Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.
With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.
Quality Assurance & Certifications
Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.
We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.
Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.
ESG-Oriented Sustainable Production
At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.
To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.
We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.
Let’s Build Your Next Insole Success Together
Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.
From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.
Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.
🔗 Learn more or get in touch:
🌐 Website: https://www.deryou-tw.com/
📧 Email: shela.a9119@msa.hinet.net
📘 Facebook: facebook.com/deryou.tw
📷 Instagram: instagram.com/deryou.tw
China insole ODM design and production
Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.
With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Indonesia OEM factory for footwear and bedding
Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.
We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Indonesia athletic insole OEM supplier
At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.China high-end foam product OEM/ODM
📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.ODM pillow factory in Indonesia
In a new study from Caltech, researchers have identified a previously unknown mechanism that allows certain viral vectors to cross the blood-brain barrier (BBB). The blood-brain barrier protects the brain from toxins and bacteria but also limits the study of the brain and development of drugs to treat brain disorders. The team discovered that an enzyme called carbonic anhydrase IV (CA-IV) enables some viral vectors to cross the BBB. This discovery may provide a new approach to designing viral vectors for research and therapeutic applications and help build resilience against emergent pathogens that could exploit the same routes for brain entry. Understanding these mechanisms could also enable personalized treatments across diverse human populations by revealing new BBB-crossing methods and expanding neuropharmaceutical delivery options. Credit: Caltech Caltech researchers discovered an enzyme that enables viral vectors to cross the blood-brain barrier, potentially aiding brain disorder drug development and research. The blood–brain barrier (BBB) is a stringent, nearly impenetrable layer of cells that guards the brain, protecting the vital organ from hazards in the bloodstream such as toxins or bacteria and allowing only a very limited set of small molecules, such as nutrients, to pass through. This layer of protection, however, makes it difficult for researchers to study the brain and to design drugs that can treat brain disorders. Now, a new study from Caltech has identified a previously unknown mechanism by which certain viral vectors—protein shells engineered to carry various desired cargo—can cross through the BBB. This mechanistic insight may provide a new approach to designing viral vectors for research and therapeutic applications. Understanding this and other new mechanisms could also give insight into how the brain’s defenses may be exploited by emergent pathogens, enabling researchers to prepare methods to block them. A timely approach to discovering putative BBB transporters: (1) Directed evolution yields diverse AAVs with enhanced brain potency. (2) BBB-specific membrane proteins are identified and screened in vitro for their ability to boost AAV potency. (3) Computational methods enable high-throughput target screening and reverse engineering of novel viral, protein, and chemical tools. Credit: Tim Shay and Gradinaru Lab at Caltech The research was conducted in the laboratory of Viviana Gradinaru (Caltech BS ’05), the Lois and Victor Troendle Professor of Neuroscience and Biological Engineering and director of the Center for Molecular and Cellular Neuroscience, part of the Tianqiao and Chrissy Chen Institute for Neuroscience at Caltech, and appears in the journal Science Advances on April 19. The study’s first authors are Timothy Shay (PhD ’15), the scientific director of Caltech’s Beckman Institute CLOVER Center; bioengineering graduate Xiaozhe Ding (PhD ’23); and CLOVER research associate Erin Sullivan. Trojan Horse Viral Vectors Though the BBB serves as the brain’s formidable defense, certain viruses have naturally evolved the ability to bypass it. For decades, researchers have studied how to use these viruses as a kind of BBB-crossing Trojan Horse; to do so, researchers scrape out the original viral cargo carried by the viruses and then use their hollow shell to ferry beneficial therapeutics or tools for research. Viral vectors with the ability to cross the BBB can deliver desired genes to the brain through a simple injection into the bloodstream and thus do not need to be invasively injected into the brain. Unfortunately, most vectors derived from naturally evolved viruses are very inefficient at crossing the BBB, and so they must be administered at high doses, increasing the risk of side effects. Carbonic anhydrase IV (CA-IV) enables enhanced brain access from the bloodstream. Fluorescent image of CA-IV protein expression on the mouse blood-brain-barrier (BBB) and AlphaFold2-generated structural model of CA-IV bound to the engineered loop of a BBB-crossing viral vector. Credit: Erin Sullivan and Xiaozhe Ding, Gradinaru Lab at Caltech Inspired by nature, Gradinaru lab has over the past decade used the process of directed evolution—a technique pioneered at Caltech by Nobel Laureate Frances Arnold—to guide the evolution of vectors and enhance their ability to cross the BBB. Over the years, the group has generated dozens of vectors with different abilities to cross the BBB and target various tissues and cell types in a variety of species. In the process, they noticed that distinct vectors can behave differently across model organisms, suggesting that these vectors may each have identified distinct and efficient paths from the bloodstream to the brain. However, although researchers knew that these vectors could cross, it was still unclear how they were crossing. Where are the entry points in the fortified wall of the BBB? In this new study, the team led by Shay, Sullivan, and Ding aimed to identify these mechanisms using a multidisciplinary approach that combines the researchers’ expertise in techniques of protein chemistry, molecular biology, and data science, respectively. First, Shay and Sullivan developed a cell-culture screen to quickly test the ability of scores of diverse proteins found on the surface of the BBB to enhance the infectivity of vectors in a dish. Ding then used an advanced computational model (based on a complex artificial intelligence program called AlphaFold) to simulate how vectors interact with the different proteins, revealing the geometries of the interactions uncovered in the screen. Next, a kind of “March Madness” competition process—which is the subject of an upcoming paper—determined which vectors interacted best with which proteins, and recapitulated the experimental results of the screen. Outlook: AAVs engineered to reach the brain from the bloodstream enable mechanistic insights into blood-brain-barrier biology, including identification of novel receptors, that can help design next-generation viral and non-viral delivery vectors for the brain and maybe also anticipate and fight emergent pathogens. Credit: Catherine Oikonomou and Viviana Gradinaru, Caltech The Role of Carbonic Anhydrase IV in BBB Crossing The team discovered a particular enzyme, called carbonic anhydrase IV (CA-IV), that enables a few different viral vectors to cross the BBB. Interestingly, CA-IV is an ancient enzyme that is found on the BBBs of many diverse species, including humans; it was not previously known to facilitate any kind of BBB-crossing process. In the future, this combined experimental and computational approach may accelerate the discovery of additional solutions to BBB crossing and the team is excited about the possibilities to apply these molecular gateways to the delivery of brain therapeutics. “Blood-brain-barrier crossing is a key biological puzzle,” says Gradinaru. “To say that an enzyme that regulates blood pH and lets us taste the fizz in soda, is an unintuitive target for helping viruses through the BBB would be an understatement. Now we can leverage CA-IV, and other exciting targets that continue to emerge from our approach rooted in identifying the mechanisms of BBB-crossing viral vectors, to help us design next-generation viral and non-viral delivery vectors for the brain. And maybe, it will also help us build resilience against emergent pathogens that could hijack the same routes for brain entry.” Understanding the range of mechanisms by which viral vectors cross into the brain is critical for enabling personalized treatments across diverse human populations. Brains, and their BBBs, vary widely across species and even among humans. In fact, an individual’s BBB can vary over their own lifetime. By revealing new BBB-crossing mechanisms, a wider range of neuropharmaceutical delivery options can be tailored to individuals with diverse biological profiles. Reference: “Primate-conserved carbonic anhydrase IV and murine-restricted LY6C1 enable blood–brain barrier crossing by engineered viral vectors” by Timothy F. Shay, Erin E. Sullivan, Xiaozhe Ding, Xinhong Chen, Sripriya Ravindra Kumar, David Goertsen, David Brown, Anaya Crosby, Jost Vielmetter, Máté Borsos, Damien A. Wolfe, Annie W. Lam and Viviana Gradinaru, 19 April 2023, Science Advances. DOI: 10.1126/sciadv.adg6618 Funding was provided by the National Institutes of Health and Caltech’s Beckman Institute for CLARITY, Optogenetics and Vector Engineering Research (CLOVER).
Mirror life presents serious dangers, primarily due to its potential to interact unpredictably with the natural world. Without natural checks like predators or antibiotics, mirror organisms could replicate uncontrollably, creating risks that scientists are only beginning to understand. Credit: SciTechDaily.com Mirror life, a concept involving synthetic organisms with reversed molecular structures, carries significant risks despite its potential for medical advancements. Experts warn that mirror bacteria could escape natural biological controls, potentially evolving to exploit resources in ways that disrupt ecosystems and pose unforeseen dangers to the environment and public health. Mirror Life “Mirror life” refers to synthetic organisms with molecular structures reversed from those found in natural life. At first glance, creating such life forms seems impossible—and for now, it is. Even the simplest mirror bacterium would be far too complex for scientists to build with current technology. However, the idea of mirror life may not remain purely theoretical. Rapid advancements in biotechnology could make its creation possible within the next few decades. If realized, mirror-image bacteria could revolutionize drug development, offering groundbreaking medical treatments. But they could also pose serious environmental risks, behaving in unpredictable and potentially harmful ways. Michael Kay, MD, PhD, a biochemistry professor at the Spencer Fox Eccles School of Medicine at the University of Utah and an expert in mirror-image pharmaceuticals, explains the science behind mirror life—and why he believes it should remain hypothetical. The Concept of Biological Chirality To talk about mirror life, I need to first talk about regular life. All of the biomolecules that make up life, like DNA and proteins, have a handedness to them, just like your hands. They could, in theory, come in a left-handed or a right-handed version. Billions of years ago, life on Earth standardized on left-handed proteins. All life that evolved from that has continued to use left-handed proteins. So when we’re talking about mirror-image life, it’s kind of like a “what if” experiment: What if we constructed life with right-handed proteins instead of left-handed proteins? Something that would be very, very similar to natural life, but doesn’t exist in nature. We call this mirror-image life or mirror life. This type of life would only exist if it was made synthetically. Potential Applications in Medicine We’re one of the leading groups that is interested in this, and our interest is largely in mirror-image therapeutics. If you give therapeutics to a person, especially protein or nucleic acid therapeutics, digestive enzymes in the body break them down rapidly, sometimes within minutes. This can make it very challenging to treat chronic illnesses in a way that’s cost-effective and convenient. But mirror molecules are not recognized by those digestive enzymes, so they have the potential to last for a much longer period of time and to open up a whole new class of therapeutics that would allow us to treat a variety of diseases that are currently challenging. Currently, we make mirror therapeutics chemically, stitching them together atom by atom. If we had mirror bacteria, which could make these for us, that could be a route to much more efficient large-scale production of mirror therapeutics. Mirror biology can be used to create long-lasting therapeutics. Importantly, mirror molecules that are created chemically cannot self-replicate, and therefore pose none of the risks of a mirror bacterium. Credit: Judah Evangelista / Kay Lab. The Risks of Synthetic Organisms A mirror organism would interact with the rest of our world in unpredictable, uncertain ways. There is a plausible threat that mirror life could replicate unchecked, because it would be unlikely to be controlled by any of the natural mechanisms that prevent bacteria from overgrowing. These are things like predators of the bacteria that help to keep it under control, antibiotics and the immune system, which are not expected to work on a mirror organism, and digestive enzymes. There is a real possibility that mirror bacteria would struggle to find enough food to eat in order to grow, but we are humble in the face of evolution. If these bacteria are able to grow at all—and there is evidence that they probably would be able to grow, at least to some extent, in our natural world—maybe, over time, they could evolve the ability to eat our food and convert it to mirror food. If that happened, that would release a brake on their growth, and then all these other controlling mechanisms, as far as we can tell, would not be effective against these mirror bacteria. But there’s a lot of uncertainty in this determination. At this point, we don’t have enough information to make a definitive estimate of what the risk would be. Technological Horizons and Future Possibilities What’s really critical is that people know there isn’t an imminent risk. We’ve never built something even close to as complex as an entire bacterial cell. It’s incredibly difficult, and new technologies are still needed to do that in a sufficiently efficient way. But we’re in a very exciting period in synthetic biology right now where new technologies, chemical synthesis, and minimal cell development are moving fast, which is why we thought this was a good time to really have this discussion as those foundational technologies are starting to develop and emerge. I think the best time estimate we have is that we’re probably one to three decades away from something like this being possible, if we made the decision to make this a priority. It would take tremendous resources and the cooperation of a huge consortium of international scientists with specialties in different aspects of cell construction. This is definitely not going to happen overnight. But it’s not so far into the future that we think that it’s something we can just hope won’t happen for a while. Mitigating Risks and Planning Ahead We hope that this commentary will kick off extensive discussions on this topic with a broad group of stakeholders. We plan to start having international conferences in the coming year to discuss the risks and work with international agencies to develop a regulatory framework that would allow us to prevent those risks. This wouldn’t affect anybody’s current research. We think there’s an opportunity, before anyone’s livelihood depends on this, to define responsible lines of research, lines that should be carefully evaluated by regulatory authorities, and the lines we shouldn’t cross. It’s important to differentiate between mirror life and benign uses of mirror technology which are already underway. Mirror drugs are in development right now, including by our lab. Because these are chemically made, there is no risk of them posing any of the dangers that exclusively come with making a self-replicating mirror bacteria. Once a mirror cell is made, it’s going to be incredibly difficult to try to put that genie back in the bottle. That’s a big motivation for why we’re thinking about prevention and regulation well ahead of any potential actual risk. Reference: “Confronting risks of mirror life” by Katarzyna P. Adamala, Deepa Agashe, Yasmine Belkaid, Daniela Matias de C. Bittencourt, Yizhi Cai, Matthew W. Chang, Irene A. Chen, George M. Church, Vaughn S. Cooper, Mark M. Davis, Neal K. Devaraj, Drew Endy, Kevin M. Esvelt, John I. Glass, Timothy W. Hand, Thomas V. Inglesby, Farren J. Isaacs, Wilmot G. James, Jonathan D. G. Jones, Michael S. Kay, Richard E. Lenski, Chenli Liu, Ruslan Medzhitov, Matthew L. Nicotra, Sebastian B. Oehm, Jaspreet Pannu, David A. Relman, Petra Schwille, James A. Smith, Hiroaki Suga, Jack W. Szostak, Nicholas J. Talbot, James M. Tiedje, J. Craig Venter, Gregory Winter, Weiwen Zhang, Xinguang Zhu and Maria T. Zuber, 12 December 2024, Science. DOI: 10.1126/science.ads9158 A commentary by Kay and other experts is published in Science as “Confronting risks of mirror life.” Banner image has been modified and is credit NIAID.
A new study warns that climate change could devastate the whitefin swellshark’s habitat, forcing it to migrate vast distances. While conservation measures offer hope, survival remains uncertain. The critically endangered whitefin swellshark, a little-known deep-sea species, faces a grim future as climate change threatens to wipe out most of its habitat. A new study predicts that up to 70% of its current range will become uninhabitable within 75 years. While a potential refuge may exist in the Great Australian Bight, the sharks will have to migrate vast distances to reach it — if they can survive the journey. Climate Change Threatens Endangered Shark A critically endangered shark species may need to find new habitats — or risk extinction — due to climate-driven changes in the ocean, according to a new study. The whitefin swellshark (Cephaloscyllium albipinnum), a deep-water catshark native to Australia’s southern and eastern coasts, faces an uncertain future. While its exact population size is unknown, the International Union for Conservation of Nature (IUCN) has classified it as Critically Endangered for years, largely due to fishing-related declines. Drastic Habitat Loss Predicted Researchers at the University of Plymouth warn that rising sea temperatures and changes in ocean chemistry, expected by the end of the century, could further threaten the species by shrinking its suitable habitat. Using a range of computer modeling, which accounted for the species’ favored habitats and forecast ocean conditions, researchers found that up to 70% of currently suitable habitats will be lost over the next 75 years. There is predicted to be an area within the Great Australian Bight that could offer whitefin swellshark populations refuge, with favourable ocean conditions and sources of the food they need to survive. A Long Journey for Survival The only challenge with that, based on current knowledge of the species’ whereabouts, are that the sharks – which grow to around 1.1 meters long – may need to move anywhere between 70km and 1100km in order to reach their potential new home. And it is likely they will not be the only species seeking refuge in the area, with a number of other marine species also likely to be forced to migrate polewards as they look to leave areas impacted by climate change. Writing in the journal PeerJ, the researchers say the vulnerability of the species to the future effects of climate change is clear. However, they do believe there is cause for hope, with Australia being one of the world’s more proactive nations when it comes to implementing conservation measures and management strategies, such as marine protected areas (MPAs). A Scientist’s Call for Urgent Action The study was carried out by Kerry Brown, a BSc (Hons) Marine Biology and Oceanography graduate from the University of Plymouth, as part of her undergraduate dissertation. She said: “Most people will probably have never seen them, but whitefin swellsharks are an incredibly pretty species. However, despite them being listed as critically endangered, we actually know very little about their behavior given its habitats are deep in the ocean. What we do know is that they have been on our planet for a very long time, so will have had to adapt to changes in their environment before. However, the threat to their future survival now is very real unless we take urgent steps to protect them.” Conservation Efforts and Future Challenges Dr. Robert Puschendorf, Associate Professor in Conservation Biology at the University of Plymouth, supervised the study and previously spent a decade working in Australia. He added: “We have seen species move into different areas of the ocean in the past, so that offers some sense of hope for the whitefin swellshark. And the marine protected areas along the Australian coast are certainly a positive factor, although whether they are in the right place for this particular species is another matter. However, it does show the authorities in the region have the willingness and means to take action. The challenges faced by this – and other – species are now very different to what they may have encountered in the past, when you consider there are now very few parts of the planet that humans haven’t damaged in some way. But our study shows we are potentially in a position where we can do something about it.” Reference: “Future climate-driven habitat loss and range shift of the Critically Endangered whitefin swellshark (Cephaloscyllium albipinnum)” by Kerry Brown and Robert Puschendorf, 20 February 2025, PeerJ. DOI: 10.7717/peerj.18787
DVDV1551RTWW78V
ODM pillow factory in China 》your competitive edge in product performance and speedBreathable insole ODM innovation factory Taiwan 》preferred by clients worldwide for fast turnaround and precisionErgonomic insole ODM support China 》committed to helping you create value through custom manufacturing